I like the quote from Isaac Asimov which goes something like:
“The most exhilarating statement in science is not ‘Eureka!’ but ‘Hmm, that’s funny’!”
Every researcher knows the feeling. When our experiments or observations produce the result we didn’t expect. That conflicts with our hypothesis – or even better conflicts with current theory.
Because we know this means progress. We have found something we can’t explain and that gives us a chance to discover something new.
Good scientists are not afraid to say “I don’t know!” Ignorance is nothing to be ashamed of. However, we should not be satisfied with it. So scientists usually add “Let’s find out!”
That’s why it is galling to hear opponents of science claim that we are an arrogant lot. That we claim to know everything. Or that we claim we can, eventually, know everything.
I confronted these sort of arguments recently in a discussion with some religious apologists (see Science and Religion: Theism and Explanatory Idleness). They were criticising scientific arrogance. Claiming that many scientists had a “science of the gaps” approach – assuming everything could eventually be explained by science alone. I challenged the claim – asking for evidence of any scientist advancing the argument. And was told to google Dawkins!
Ah, the Dawkins who doesn’t exist but has been invented as an apologist voodoo doll (see The Dawkins Delusions).