More poor-quality research promoted by anti-fluoride activists

Anti-fluoridation propagandists must think all their Christmases have come at once. They at last have a “peer-reviewed” scientific paper they can claim supports their position. What’s more, it is the second such paper to appear in the last month.

But they really are resorting to arguments of quantity (2 papers) over quality. This new paper claiming a link between community water fluoridation (CWF) and Attention-Deficit Hyperactivity Disorder (ADHD) is of just as poor quality as the earlier one claiming a link with hypothyroidism. Both papers are speculative, ignore other relevant factors, and “prove” nothing.

I discussed the hypothyroidism paper in the article Paper claiming water fluoridation linked to hypothyroidism slammed by experts. The new ADHD paper is:

Malin, A. J., & Till, C. (2015). Exposure to fluoridated water and attention deficit hyperactivity disorder prevalence among children and adolescents in the United States: an ecological association. Environmental Health, 14.

Here are my thoughts on this paper.

Exploratory investigation – correlation not causation

The authors have simply taken existing online data and searched for a statistically signficant relationship. They have explored the limited data sets used – not attempted to prove an effect. After all, correlation does not prove causation – the graph below shows an example of how correlation can often produce meaningless results.

The data sets Malin and Till (2015) used are both from the USA Centers fo disease Control (CDC).

  1. State-based attention-deficit hyperactivity disorder (ADHD) prevalence (Visser et al., 2014);
  2. Numbers of people receiving fluoridated water from public water supplies in each state obtained from the CDC.

Note, they did not use data for individual children exhibiting symptoms of ADHD  determined by  a health professional. The data was from random surveys “in which parents were contacted via telephone and asked about the emotional and physical well-being of a randomly selected child from their household.” Similarly they did not use data for dietary intake of fluoride by individual children but used “the percentage of the U.S. population on public water systems that receives optimally fluoridated drinking water.”

They have assumed these data are reliable proxies for occurrence of ADHD and fluoride dietary intake. But the data could represent other factors as well.

For example, parental reporting of ADHD could differ from state to state because of differences in parental educational levels and ideological attitudes. People in  different sates may not have the same level of knowledge, awareness or acceptance of such behaviours. Malin and Till themselves acknowledge ADHD reporting is higher for parents with a high school education than for parents who did not graduate high school (Visser (2014). Parental education levels are likely to vary from state to state.

The availability of CWF can be dependent on the size of urban areas for both technical reasons and because of  recognised willingness for innovation from large and high status city leaders (Crain, 1996) so that the state prevalence used could be acting as a proxy for the distribution of urban areas of different sizes, and the relative urban/rural distributions in different sates. A correlation may indicate nothing more than a relationship between city sizes and parental education.

The authors themselves warn their study has limitations, saying it is:

“an ecological design that broadly categorized fluoride exposure as exposed versus non-exposed rather than collecting information related to concentration of fluoride and patterns and frequency of exposure or outcome at the individual level. Future research could explore the relationship between exposure to fluoridated water and the occurrence of ADHD at the individual level.”

And, again, we should always keep in mind that correlation does not prove causation.

The starting hypothesis

Inevitably any serious exploratory investigation should start with a working hypothesis. As psychologists the authors are presumably interested in ADHD and its causes. But why investigate state prevalence of CWF instead of any of the other factors indicated in this condition. In fact they list a range of candidates from arsenic and lead to food additives and food colouring. Granted, they saw CWF as a field ripe for plucking as they say fluoride “has received virtually no attention in the ADHD literature.” But I would have expected them to at least include these other known factors as confounders in their study.

I think the answer lies with their biased reading of the literature. They start with the claim that fluoride is a “widespread environmental neurotoxin,”  but only really cite Grandjean and Landrigan (2014) and the closely-related meta-analysis of Choi et al., (2012) to support this claim. I have discussed those papers and their problems in  Repeating bad science on fluoride and Controversial IQ study hammered in The Lancet. A major problem with that work is it involved areas of endemic fluorosis where fluoride intake is high so it is not directly relevant to CW. In fact, the authors’ bias is indicated by the fact they did not cite Broadbent et al., (2014) which showed no neurotoxic effects of CWF. Broadbent et al.’s paper is directly relevant to CWF – Choi et al.’s is not. (I discussed the differences as indicated by dental fluorosis data in my article Water fluoridation and dental fluorosis – debunking some myths

I feel this omission indicates that the authors resort to the special pleading of anti-fluoride activists in the citations they used for justifying their starting hypothesis. The also rely on studies of rats fed very high levels of fluoride, such as that of  Mullenix et al., (1995), and then use her weak argument to claim relevance to CWF by comparing  rat blood plasma F levels to those for humans ingesting high levels of fluoride. (See my article Peer review of an anti-fluoride “peer review” for a discussion on this). Similarly, although acknowledging the high F intake levels of most of the studies reviewed by Choi et al., (2012), they excuse this by referring to the one study with low levels (0.88 mg/L) – ignoring the fact this was a one and a half page article in a newsletter describing measurements in an iodine deficient area. In this study (Lin, et al., 1991) children from low iodine areas were compared with a group from another area that had received iodine supplementation. About 15% of the children suffered mental retardation, 69% of these exhibited subclinical endemic cretinism. The effect of iodine supplementation was clear, the effect of fluoride not so clear. (See Peer review of an anti-fluoride “peer review” for further discussion of this).

So, I think the justification for their starting hypothesis is hardly objective

“Natural” vs “artificial” fluoride

Despite  problems with justification for their hypothesis they did find a significant positive relationship between the US state prevalence of parent-reported ADHD in children and the state proportion of water supplies with optimum levels of fluoride. Again, not a proof of their hypothesis, but interesting data to consider nonetheless. They found inclusion of socio-economic status data improved the relationship but did not consider other relevant confounding factors like parental education and exposure to relevant chemicals.

In contrast, the relationship they found between ADHD prevalence and natural fluoride prevalence (at optimum level or above) was negative and statistically signficant. This actually conflicts with their starting hypothesis of chemical neurotoxicity based on the work of Choi et al., (2014) and Grandjean and Landrigen (2014). While they concede the data really doesn’t allow a conclusion they suggest it could result from the ADHD effect being specific to “fluoridation chemicals” and not fluoride itself.

This leads them to suggest a theoretical “pathway” for CWF contributing to ADHD – the corrosion of lead-bearing plumbing by fluorosilicic acid. Trouble is this ignores the well established fact that fluorosilicates used in CWF decompose to form silica and the hydrated fluoride anion when diluted in water. Malin and Till seem oblivious to work showing this and rely instead on citation of the poor quality work of Masters and Coplan to support this “pathway.” Another example of their citation bias.

But their proposal does raise an important question. Given that lead is one suggested cause of ADHD why did they not concentrate their exploratory analysis of data for lead intake by children in different states, rather than CWF prevalence? Or at least include lead levels as confounders in their statistical analysis.

The thyroid story again

Their second suggested “pathway” is via suppression of thyroid gland activity by fluoride. But, again, this hypothesis does raise the question of other causes, in particular iodine deficiency. (See my discussion of Peckham’s paper – Paper claiming water fluoridation linked to hypothyroidism slammed by experts – for more on this). If this was part of their starting hypothesis then why not consider data for state prevalence of iodine deficient diets of children? Or or include this as a confounder in the analysis?

I find it interesting that despite declaring a starting hypothesis based on the chemical toxicity claims of Choi et al., (2012) and Grandjean and Landrigen (2014), Malin and Till have not proposed any theoretical “pathway” involving direct neurotoxicity of fluoride itself to explain their result. This makes their unwillingness to consider other relevant confounding factors even more obvious.

Conclusions

As I wrote above correlation is not causation  and this study does not “prove” anything. The observed “link”could represent a number of other relationships which are not directly associated with CWF. The analysis also suffers from a lack of consideration of obvious confounding factors.

I believe this is the sort of problem that arises when researchers have a committment to a starting hypothesis and peer review systems are inadequate. Such studies are a problems when published because ideologically motivated activists love to cherry-pick them to claim “scientific support” for their cause. This is not helped when the researchers themselves climb on the activist bandwagon and attempt to claim more for their findings that is really justified.

I think Malin and Till have done this with the press release from their department – Fluoride in tap water associated with ADHD in children, researchers find. It is one thing to say:

“Our findings showed that artificial fluoridation prevalence in 1992 predicted ADHD prevalence in 2003, 2007 and 2011 among children and adolescents in the United States, and that was after controlling for median household income.”

But the careful claim their “findings showed” a “prediction” is far too easily seen as proof in the mind of the lay-reader. Worse, they draw unwarranted conclusions from their limited work:

“As citizens of Toronto, living in an artificially fluoridated community, I think we need to ask ourselves whether this is still a worthwhile practice.”

One can only pose such questions in the context of an objective assessment of their own work together with other research of possible harmful and beneficial effects of CWF. I think their biased choice of citations in this paper shows they are not capable of doing this.

On the other hand reviews such as the recent NZ Fluoridation Review, Health effects of water fluoridation : A review of the scientific evidence, have done this. Community leaders should be going to such sources for their information and not rely on cherry-picked poor quality studies like Malin and Till (2015) which will be promoted to them by anti-fluoride propagandists and activists.

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9 responses to “More poor-quality research promoted by anti-fluoride activists

  1. The link is fluoride’s anti-cholinesterase effect. They put their results up and I have sent them the possible link, which I could not have thought of if they had not published.

    Saliva flows when the cholinesterase stimulates the nerves. Anti-cholinesterase is supposed to regulate it back but fluoirde is a drug which suppresses that.

    It’s a bit complex, but anyone who drinks much alcohol knows about getting dehydrated. One of the effects of the drug alcohol is to suppress the anti-diuretic hormone.

    The saliva protects the teeth but the drug, fluoirde causing that has other effects.

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  2. Ken you have not allowed for, as it says in this study, “natural fluoride” could be at a mg/l level lower than “optimal fluoridation,” or at a higher mg/l level than “optimal fluoridation.”

    The study said:
    “Artificial water fluoridation prevalence was significantly positively associated with ADHD prevalence, while natural water fluoridation prevalence was either negatively or not significantly associated with it. Although this could imply that the relationship between
    exposure to fluoridated water and increased ADHD prevalence is specific to fluoridation chemicals, the high variability in naturally occurring fluoride concentrations (0.1 mg/L – 15.9mg/L) [21] within states prevents this conclusion from being made. Specifically, natural fluoride concentration could potentially be confounding the relationship between natural fluoridation prevalence and ADHD prevalence leading to a misleading result. For example,
    counties with low natural fluoridation prevalence could have high concentrations of naturally occurring fluoride that pose a greater neurodevelopmental risk than high prevalence of low concentrations of naturally occurring fluoride.”

    And you seem to have missed entirely, “Thus, future research
    controlling for the high variability in natural fluoride concentration is necessary to more validly examine this relationship.”

    As regards lead they are asking about it.

    In Dunedin the lead levels had been high in the water. At a simillar time to the start of fluoridation there, they started to add calcium (lime) to the water to lower the acidity. The lower acidity means less lead dissolves into the water. (And that does not appear to have been taken into account by the study you hold up high, the “Royal Society Review.” It has argued against many claims but let Broadbent get through though Broadbent ignored that.)

    The Dunedin Council still advises to run your tap for a bit before using the water for drinking.

    So I need to get back to the authors to see if they could note the level of water hardness (lime – calcium) in the supplies, whether fluoridated or not.

    And I shall also write to them that besides saying: “Although more research is needed to investigate the relationship between exposure to fluoridated water and increased ADHD prevalence, there are two main pathways by which exposure to fluoridated water could theoretically contribute to the disorder,” why they do not expand on their rat/acetylcholine pathway reference, besides lead and thyroid suppression. Many soft drinks are high on acidity which could aggravate fluoride’s troublesome effects in affecting the acetylcholine pathways.

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  3. Soundhill, please justify your claim I had “not allowed for” something. On U a fool would make that claim just because I did not quote the whole paper.

    >

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  4. Ken, you wrote: “While they concede the data really doesn’t allow a conclusion they suggest it could result from the ADHD effect being specific to “fluoridation chemicals” and not fluoride itself.”

    They are not suggesting that, quite the opposite.

    Please read again:

    “Although this could imply that the relationship between
    exposure to fluoridated water and increased ADHD prevalence is specific to fluoridation chemicals, the high variability in naturally occurring fluoride concentrations (0.1 mg/L – 15.9
    mg/L) [21] within states prevents this conclusion from being made.”

    “Could,” was not a good enough word to use when they really meant, “could at first seem to imply.” But they go on to say that conclusion is prevented (by the high variability in naturally occurring fluoride concentrations (0.1 mg/L – 15.9
    mg/L) [21] within states”).

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  5. Continue reading the paper Soundhill.

    You have simply quoted their argument which I described as them conceding the data didn’t allow a conclusion. However, despite this they went on to discuss the fluorosilicate and Pb explanation as their first “pathway,” and indulged in special pleading for that pathway by citing the poor quality papers.

    Stop trying to attribute your poor comprehension to me.

    >

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  6. Ken, first let the matter of “naturally fluoridated,” be understood in the way they are using it, which is as opposed to “adjusted.” On another website Steve Slott has done a big spiel in reply to this paper about how there is no difference between natural and artificial fluoride. He is shooting off at a straw man.

    This from their ref 21:
    “Adjusted fluoridation is the conscious maintenance of the optimal fluoride concentration in the water supply for reducing dental caries and minimizing the risk of dental fluorosis. The optimal concentration may be accomplished by adding fluoride chemicals to fluoride deficient water; by blending two or more sources of water naturally containing fluoride to achieve the optimal
    concentration; or partial defluoridation, that is, removing naturally
    occurring excessive fluorides to obtain the recommended level. Water systems are considered to have optimal level of natural fluoride if they contain naturally occurring fluoride at or above the minimum recommended control range. Water systems and communities with optimally adjusted fluoride and
    naturally occurring fluoride in water are listed in this publication.
    Adjusted water systems are fluoridated at the optimal level according to the average maximum daily air temperature in the community. (Recommended concentrations, according to National Interim Primary Drinking Water Regulations, 1975, are shown in Table A. ) Although the term “natural fluoridation” has no particular scientific or official connotation, it has been used in this publication for the sake of simplification.”

    Your heading,

    ““Natural” vs “artificial” fluoride”,

    then needs to be noted as different from the meaning Steve and probably others are falling into. In terms of fluoride It is only about whether the levels have been adjusted. It could be mixing a smaller amount of water from a well with high natural fluoride with a larger amount of water from a river with low natural fluoride to artificially optimise the level. But other chemicals could be added, perhaps dolomite, a sort of lime with magnesium in it, too, but sometimes with lead also. I guess they are careful to test their lime.

    You wrote: “While they concede the data really doesn’t allow a conclusion they suggest it could result from the ADHD effect being specific to “fluoridation chemicals” and not fluoride itself.”

    They are not “conceding” anything, nor are they suggesting anything. They are only ruling out a conclusion that some few other people might think.

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  7. Ken you wrote: “In contrast, the relationship they found between ADHD prevalence and natural fluoride prevalence (at optimum level or above) was negative and statistically signficant.”

    I do not see where you get that, “at optimum level or above.”

    Optimum is 0.7 at the moment. You are excused if you mistook 1 and 7 whatever they look like on your font. But you need to do some re-writing.

    “The naturally occurring fluoride concentrations (0.1 mg/L – 15.9mg/L)”

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  8. Soundhill, howabout you copy and past their first suggested “pathway?”

    >

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  9. Ken, quite early on they wrote:
    “Rats exposed to fluoridation chemicals have been shown to exhibit ADHD-like symptoms.”
    “Rats with fluorosis also tend to have significant decreases in neural nicotinic acetylcholine receptors (nACHRs) and inhibited cholinesterase expression [30-33], both of which could
    interfere with attentional processes [34].”

    The fluoride levels are rather higher.

    But I think the tails of the distribution need looking at.

    I think it is important because of the fluoride – saliva increase through that pathway which Westendorf references, and that saliva protects teeth.

    Natural saliva has a very low level of fluoride yet it keeps teeth good if it can get to them as seen in Urewera Maori where they had only about 1% caries before starting to eat food which sticks to the teeth and stops saliva getting to them.

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